HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 46317431, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-Pyridinylboronic acid | HCID 2734378 | — |
| Reactant | 4-Bromo-2-fluoro-benzoic acid methyl ester | HCID 11345311 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Dimethoxyethane ethanol water | HCID 86587095 | — |
| Product | HCID 46317431 | HCID 46317431 | — |
Reaction Steps
A mixture of EXAMPLE 50A (5 g), 3-pyridinylboronic acid (4 g) and dichlorobis(triphenylphosphine)-palladium (II) (1.1 g) in 7:3:2 DME/water/ethanol (200 mL) and 2M aqueous Na2CO3 solution (1 mL) at 80° C. was stirred 18 hours, cooled and filtered. The filtrate was partitioned between ethyl acetate and water, and the ethyl acetate layer washed with water and concentrated. The concentrate was flash chromatographed on silica gel with 1:2 ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697736B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-e8f2c6615365443fac76fa770a216954 |
| Source note | uspto-grants-2014_04 |