HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4-(1-Methylpiperidin-4-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 4-(Piperidin-4-yl)benzoic acid | HCID 18002462 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(1-Methylpiperidin-4-yl)benzoic acid | HCID 18002455 | — |
Reaction Steps
A solution of 4-piperidin-4-ylbenzoic acid (0.5 g) and 36% formaldehyde in water (0.175 mL) in methanol (5 mL) was treated with sodium cyanoborohydride (0.13 g) and acetic acid (0.5 mL), stirred for 18 hours and concentrated. The concentrate was flash chromatographed on silica gel with 10% methanol/dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697736B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-c25f0169937a4962a61a7c007a1e9dcb |
| Source note | uspto-grants-2014_04 |