Sodium sulfide octahydrate → HCID 178512606, compound

HRID 236648Notes

Reaction equation

HRID 236648 reaction equation
O.O.O.O.O.O.O.O.[S-2].[Na+].[Na+].[NH:12]([C:16]1[S:17][CH:18]=[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[N+:27]([O-])=O)[N:20]=1)[C:13]([NH2:15])=[NH:14]>CO.O>[NH:12]([C:16]1[S:17][CH:18]=[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[NH2:27])[N:20]=1)[C:13]([NH2:15])=[NH:14]

Participants

5

Reactant 2

HCID 131714387Sodium sulfide octahydrateHCID 178512607HCID 178512607, compound

Product 1

HCID 178512606HCID 178512606, compoundYield 82.8%

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

A solution of 57 gm of sodium sulfide octahydrate in 400 ml of methanol and 120 ml of water was added dropwise over a period of 300 minutes to a hot (60° C.) solution of 16.9 gm of 2-guanidino-4-(2-nitro-phenyl)-thiazole in 120 ml of methanol. After an additional 2 hours of heating at 60° C., the solution was filtered with charcoal and evaporated to dryness. The residual solid was suspended in water, filtered off and dried, yielding 12.4 gm of the title compound, m.p. 198°-200° C.

Workup

  1. filtrationthe solution was filtered with charcoal
  2. customevaporated to dryness
  3. filtrationfiltered off
  4. customdried

Sources & evidence

ORD record
ord-ef6670b6b4be41a397bc1b5943c174e5
Source dataset
uspto-grants-1987_02
Patent number
US04645841

Reaction notes

Loading…