1-(2-Pyridyl)-2-thiourea → HCID 178434162, compound

Participants

Reaction Steps

According to Scheme 4 Step 5: A solution of a mixture of 5,5-dibromo-3-methyl-6,7-dihydro-1H-indazol-4(5H)one, 5-bromo-3-methyl-6,7-dihydro-1H-indazol-4(5H)-one (37.5:62.5, 173 mg) and of 1-(pyridin-2-yl)thiourea (0.67 mmol, 102 mg) in EtOH (2.4 mL) was stirred under reflux for 3 hours. The precipitate formed was filtered, was washed with a saturated solution of NaHCO3, water, EtOH and Et2O and was dried to yield 8-methyl-N-(pyridin-2-yl)-5,6-dihydro-4H-thiazolo[4,5-e]indazol-2-amine (46 μmol, 13 mg) as a white solid.

Provenance & Evidence