3-Methylamino phenacyl bromide hydrobromide → HCID 178482140, Verbindung

HRID 236653Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 236653
Br.[CH3:2][NH:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7](=O)[CH2:8]Br.[C:14]([NH:17][C:18]([NH2:20])=[S:19])(=[NH:16])[NH2:15]>C(O)C>[NH:17]([C:18]1[S:19][CH:8]=[C:7]([C:6]2[CH:11]=[CH:12][CH:13]=[C:4]([NH:3][CH3:2])[CH:5]=2)[N:20]=1)[C:14]([NH2:16])=[NH:15]

Komponenten

4

Edukt 2

HCID 202163843-Methylamino phenacyl bromide hydrobromideHCID 178513045HCID 178513045, Verbindung

Produkt 1

HCID 178482140HCID 178482140, VerbindungAusbeute 71,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 20 gm of 3-methylamino phenacyl bromide hydrobromide, 7.65 gm of amidinothiourea and 100 ml of ethanol was refluxed for 4 hours, and then cooled to room temperature. The dihydrobromide which separated out was filtered off, dissolved in water, and the solution was made alkaline with 10% sodium hydroxide. The free base was collected and dried, yielding 11.5 gm of the title compound, m.p. 198°-200° C.

Aufarbeitung

  1. temperaturewas refluxed for 4 hours
  2. customThe dihydrobromide which separated out
  3. filtrationwas filtered off
  4. dissolutiondissolved in water
  5. customThe free base was collected
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-6ddf81c818434022a7894ae1b8e32abd
Quelldatensatz
uspto-grants-1987_02
Patentnummer
US04645841

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