反应详情

A mixture of 20 gm of 3-methylamino phenacyl bromide hydrobromide, 7.65 gm of amidinothiourea and 100 ml of ethanol was refluxed for 4 hours, and then cooled to room temperature. The dihydrobromide which separated out was filtered off, dissolved in water, and the solution was made alkaline with 10% sodium hydroxide. The free base was collected and dried, yielding 11.5 gm of the title compound, m.p. 198°-200° C.

1. temperaturewas refluxed for 4 hours
2. customThe dihydrobromide which separated out
3. filtrationwas filtered off
4. dissolutiondissolved in water
5. customThe free base was collected
6. customdried