Acetic Acid → HCID 66812215, compound

Participants

Reaction Steps

To a degassed solution of (S)-6-fluoro-N—((R)-1-phenylethyl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine (8.96 g, 0.029 mol) in a mixture of THF (60 ml), MeOH (20 ml) and AcOH (10 ml) was added 20% Pd(OH)2 (1.34 g). The mixture was evacuated three times and the reaction was set under 1 atm (balloon) H2. It was stirred at rt for 10 h and filtered over celite. The pad was rinsed with THF/MeOH and the filtrate was concentrated to 50 ml. The residue was dissolved in EA, and washed with 1N NaOH. The aqueous phase was extracted with EA and the combined organic phases were dried over Na2SO4, filtered and concentrated in vacuo to afford the title compound as a white solid.

Provenance & Evidence