Hydrochloric Acid → HCID 86678182, compound

Participants

Reaction Conditions

Reaction Steps

To a cold (0° C.) solution of (S)-ethyl 2-(3-((tert-butoxycarbonyl)amino)-6-fluoro-3,4-dihydro-1H-carbazol-9(2H)-yl)acetate (8.2 g, 0.021 mol) in dry DCM (50 ml) was added dropwise 4N HCl in dioxane (52.5 ml, 0.21 mol). The resulting reaction mixture was stirred at 0° C. for 2 h and then at rt for 5 h. The reaction mixture was concentrated in vacuo and the resulting solid was dissolved in EtOH (70 ml) and was added at 0° C. 3N HCl in EA (7 ml). The reaction mixture was stirred at reflux overnight. After cooling to rt, the reaction mixture was concentrated in vacuo to afford the title compound as a beige powder.

Provenance & Evidence