HCID 86678182, compound → HCID 86678186, compound

HRID 2366565Notes

Reaction equation

HRID 2366565 reaction equation
[ClH:1].[NH2:2][C@@H:3]1[CH2:15][C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([F:16])[CH:12]=3)[N:7]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:6]=2[CH2:5][CH2:4]1.C(OC(N[C@H]1CC2C3C(=CC=C(F)C=3)N(CC(OCC)=O)C=2CC1)=O)C1C=CC=CC=1>>[ClH:1].[NH2:2][C@H:3]1[CH2:15][C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([F:16])[CH:12]=3)[N:7]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:6]=2[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 86678182HCID 86678182, compoundHCID 86678188HCID 86678188, compound

Product 1

HCID 86678186HCID 86678186, compound

Procedure

Following the same procedure as (S)-ethyl 2-(3-amino-6-fluoro-3,4-dihydro-1H-carbazol-9(2H)-yl)acetate hydrochloride but using (R)-ethyl 2-(3-(((benzyloxy)carbonyl)amino)-6-fluoro-3,4-dihydro-1H-carbazol-9(2H)-yl)acetate, the title compound was obtained as a white solid.

Sources & evidence

ORD record
ord-818e5841e950425e84937a6cbc2286c2
Source dataset
uspto-grants-2014_04
Patent number
US08697869B2

Reaction notes

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