Sodium Bicarbonate → HCID 57447024, compound

Participants

Reaction Steps

Ammonium acetate (20 g) and ethyl 6-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)hexanoate (4.11 g, 11.6 mmol) were heated overnight at 140° C. in a sealed vessel. The reaction was allowed to cool to ambient temperature, and saturated aqueous sodium bicarbonate was added. The mixture was extracted with chloroform (3×), and the extracts were combined and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel (eluting with 95:5 dichloromethane:methanol) to provide 1.7 g of 6-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)hexanamide.

Provenance & Evidence