4-Toluenesulfonyl chloride → HCID 57447023, compound

Participants

Reaction Steps

6-(2-Propyl-1H-imidazo[4,5-c]quinolin-1-yl)hexanamide (1.7 g, 5.2 mmol) was treated with mCPBA (3.61 g, 15.7 mmol) followed by ammonium hydroxide (40 mL) and p-toluenesulfonyl chloride (1.49 g, 7.84 mmol) according to the method described in Part D of Example 8. The crude product was purified as described in Part D of Example 8 to provide 0.137 g of 6-(4-amino-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)hexanamide as tan needles, mp 210-211° C.

Provenance & Evidence