Propylamine → HCID 57447026, compound

Participants

Reaction Steps

A solution of ethyl 6-(1H-imidazo[4,5-c]quinolin-1-yl)hexanoate (7.0 g, 22.5 mmol) and n-propylamine (11.1 mL, 135 mmol) in THF (10 mL) was heated at 100° C. for ten days in a sealed high-pressure vessel. Additional n-propylamine (20 mL) was added after three days and again after seven days. After ten days, the reaction was concentrated under reduced pressure to provide 7.0 g of 6-(1H-imidazo[4,5-c]quinolin-1-yl)-N-propylhexanamide.

Provenance & Evidence