4-Toluenesulfonyl chloride → HCID 58970365, compound

Participants

Reaction Steps

6-(1H-Imidazo[4,5-c]quinolin-1-yl)-N-propylhexanamide (7.0 g, 26 mmol) was treated with mCPBA (8.68 g, 37.7 mmol) followed by ammonium hydroxide (40 mL) and p-toluenesulfonyl chloride (8.01 g, 42.1 mmol) according to the method described in Part D of Example 8. The crude product was triturated with ethyl acetate and recrystallized twice from methanol:water to provide 2.00 g of 6-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)-N-propylhexanamide as brown needles, mp 128-130° C.

Provenance & Evidence