4-Toluenesulfonyl chloride → HCID 57447029, compound

Participants

Reaction Steps

1-(6-Morpholin-4-yl-6-oxohexyl)-1H-imidazo[4,5-c]quinoline (3.09 g, 8.79 mmol) was treated with mCPBA (3.54 g, 15.4 mmol) followed by ammonium hydroxide (50 mL) and p-toluenesulfonyl chloride (3.26 g, 17.4 mmol) according to the method described in Part D of Example 8. The crude product was purified as described in Part C of Example 10 to provide 0.422 g of 1-(6-morpholin-4-yl-6-oxohexyl)-1H-imidazo[4,5-c]quinolin-4-amine as brown needles, mp 166-168° C.

Provenance & Evidence