Sodium Hydroxide → HCID 69506708, compound

HRID 2366616Notes

Reaction equation

HRID 2366616 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][C:5]1[N:6]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([O:25]CC)=[O:24])[C:7]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:10]=[CH:9][C:8]=2[N:17]=1.[OH-].[Na+]>>[CH3:1][O:2][CH2:3][CH2:4][C:5]1[N:6]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[C:7]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:10]=[CH:9][C:8]=2[N:17]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 69506752HCID 69506752, compound

Product 1

HCID 69506708HCID 69506708, compoundYield 75%

Procedure

Ethyl 6-[2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]hexanoate (12.05 g, 32.61 mmol) was treated with sodium hydroxide (1.70 g, 42.4 mmol) according to a modification of the method described in Part A of Example 11. The reaction was stirred overnight at ambient temperature to provide 8.35 g of 6-[2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]hexanoic acid after the aqueous work-up procedure.

Sources & evidence

ORD record
ord-c7c507f7aba344f58a1b931c00a7fd8a
Source dataset
uspto-grants-2014_04
Patent number
US08697873B2

Reaction notes

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