Potassium Carbonate → HCID 57447017, compound

Participants

Reaction Steps

Ethyl 6-(3-nitroquinolin-4-ylamino)hexanoate (27.1 g, 81.8 mmol, prepared as described in Parts A and B of Example 6) was treated with sodium hydrosulfite (49.8 g, 286 mmol), potassium carbonate (44.6 g, 323 mmol), and ethyl viologen dibromide (0.306 g, 0.818 mmol) according to a modification of the method described in Part A of Example 8. After the reaction was stirred overnight, additional sodium hydrosulfite (5.0 g, 29 mmol) was added, and the reaction was stirred for one additional hour. The organic layer was separated, washed three times with water, and concentrated under reduced pressure to provide 24 g of ethyl 6-(3-aminoquinolin-4-ylamino)hexanoate.

Provenance & Evidence