4-Toluenesulfonyl chloride → HCID 57447038, compound

Participants

Reaction Steps

N-Methyl-3-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)propanamide (4.7 g, 13 mmol) was treated with mCPBA (6.58 g, 38.2 mmol) followed by ammonium hydroxide (40 mL) and p-toluenesulfonyl chloride (3.27 g, 17.2 mmol) according to the method described in Part D of Example 8. The crude product was purified as described in Part D of Example 8 to provide 0.674 g of 3-(4-amino-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)-N-methylpropanamide as a tan powder, mp 177-178° C.

Provenance & Evidence