Hydrochloric Acid → HCID 69506691, compound

Participants

Reaction Steps

3-(2-Propyl-1H-imidazo[4,5-c]quinolin-1-yl)propanamide (3.9 g, 14 mmol) was treated with mCPBA (6.19 g, 26.9 mmol) followed by ammonium hydroxide (50 mL) and p-toluenesulfonyl chloride (4.6 g, 24 mmol) according to the method described in Part D of Example 8. The crude product was dissolved in methanol, and hydrogen chloride (1.25 mL of a 1 M solution in diethyl ether) was added. The resulting solid was isolated by filtration and dried overnight under high vacuum to provide 0.477 g of 3-(4-amino-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)propanamide hydrochloride as tan needles, mp 242-243° C.

Provenance & Evidence