Ethyl orthoformate → HCID 57447041, compound

Participants

Reaction Steps

The method described in Part A of Example 10 was used to treat ethyl N-(3-aminoquinolin-4-yl)-β-alaninate (10.0 g, 38.6 mmol, prepared in Part A of Example 18) with triethyl orthoformate (8.98 mL, 54.0 mmol). The reaction was complete in three hours. The reaction mixture was filtered to remove a precipitate and then subjected to the work-up procedure to provide 9.7 g of ethyl 3-(1H-imidazo[4,5-c]quinolin-1-yl)propanoate.

Provenance & Evidence