Triethylamine → HCID 68873567, compound

Participants

Reaction Conditions

Reaction Steps

4-Chloro-3-nitroquinoline (76.1 g, 365 mmol) was treated with β-alanine ethyl ester hydrochloride (50.0 g, 326 mmol) in the presence of triethylamine (94.5 mL, 678 mmol) and potassium carbonate (37.45 g, 271.2 mmol) according to a modification of the method described in Part A of Example 15. Before the addition of β-alanine ethyl ester hydrochloride, the reaction was cooled to 0° C. After this addition, the reaction was stirred for four hours at ambient temperature and subjected to the work-up procedure to provide 105 g of ethyl N-(3-nitroquinolin-4-yl)-β-alaninate.

Provenance & Evidence