HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl orthoacetate → HCID 57447045, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl orthoacetate | HCID 15050 | — |
| Reactant | HCID 68874499 | HCID 68874499 | — |
| Catalyst | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Product | HCID 57447045 | HCID 57447045 | 85.5% |
Reaction Steps
Ethyl N-(3-aminoquinolin-4-yl)-β-alaninate (15.0 g, 57.8 mmol) was treated with trimethyl orthoacetate (10.3 mL, 81.0 mmol) and pyridinium p-toluenesulfonate (0.200 g) according to the method described in Part A of Example 10 to provide 14.0 g of ethyl 3-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)propanoate as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697873B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-29f92d08c2d8498986293aa36ae7c860 |
| Source note | uspto-grants-2014_04 |