Ammonium Acetate → HCID 57447049, compound

Participants

Reaction Conditions

Reaction Steps

Ammonium acetate (7 g) and ethyl 3-(2-ethoxymethyl-1H-imidazo[4,5-c]quinolin-1-yl)propanoate (5.0 g, 15 mmol, prepared in Part A of Example 23) were stirred overnight at 125° C. in a sealed vessel. The reaction was allowed to cool to ambient temperature, and water (20 mL) was added. A precipitate formed and was isolated by filtration, washed with saturated aqueous sodium bicarbonate, and dried to provide 2.4 g of 3-[2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propanamide as a tan powder.

Provenance & Evidence