HCID 57447016, compound → HCID 57447061, compound

Participants

Reaction Steps

A mixture of 1-(6-morpholin-4-yl-6-oxohexyl)-2-propyl-1H-imidazo[4,5-c]quinolin-4-amine (2.0 g, 4.9 mmol), platinum (IV) oxide (1.5 g, 6.6 mmol), and trifluoroacetic acid (50 mL) was placed in a Parr vessel and shaken under hydrogen pressure (50 psi, 3.5×105 Pa) for 24 hours. The trifluoroacetic acid was removed under reduced pressure, and the residue was sonicated with 10% aqueous sodium hydroxide. The resulting solid was mixed with material from another run and recrystallized from water. The crystals were isolated by filtration and dried overnight at 80° C. to provide 0.978 g of 1-(6-morpholin-4-yl-6-oxohexyl)-2-propyl-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolin-4-amine as a white crystalline powder, mp 162-163° C.

Provenance & Evidence