Ammonium Acetate → HCID 57447063, compound

Participants

Reaction Conditions

Reaction Steps

Ammonium acetate (4.0 g) and ethyl 3-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)propanoate (4.5 g, 17 mmol, prepared as described in Parts A through C of Example 22) were heated for three days at 130° C. in a sealed vessel. The reaction was allowed to cool to ambient temperature, and water was added. The mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (eluting with dichloromethane:methanol in a gradient from 90:10 to 85:15) to provide 2.20 g of 3-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)propanamide as a tan solid.

Provenance & Evidence