HCID 69506714, compound → HCID 57455388, compound

Participants

Reaction Steps

A mixture of ethyl 4-(3-nitro[1,5]naphthyridin-4-ylamino)butanoate (5.0 g, 16 mmol), 5% platinum on carbon (0.50 g), and ethyl acetate (80 mL) was added to a Parr vessel, and the reaction was placed under hydrogen pressure (30 psi, 2.1×105 Pa) for 2.5 hours. The reaction mixture was filtered through a layer of CELITE filter agent, and the filter cake was washed with ethyl acetate (50 mL). The filtrate was concentrated under reduced pressure to provide ethyl 4-(3-amino[1,5]naphthyridin-4-ylamino)butanoate as a yellow oil.

Provenance & Evidence