Dimethylamine → HCID 57447094, compound

Participants

Reaction Conditions

Reaction Steps

Dimethylamine (15 mL of a 40% aqueous solution) was added to a solution of ethyl 3-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)propanoate (4.02 g, 12.9 mmol, prepared in Part B of Example 18) in THF (7 mL), and the reaction mixture was heated at 110° C. overnight in a pressure vessel. The reaction was allowed to cool to ambient temperature and concentrated under reduced pressure to provide 4.1 g of N,N-dimethyl-3-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)propanamide as a dark brown solid.

Provenance & Evidence