Sodium Bicarbonate → HCID 57447097, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 5-(2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)pentanoate (10.0 g, 28.2 mmol, prepared in Example 46) and ammonium acetate (10 g) were sealed in a high-pressure vessel, heated for two days at 130° C., and then allowed to cool to ambient temperature. Saturated aqueous sodium bicarbonate was added, and the mixture was then extracted with dichloromethane. The combined organic fractions were washed sequentially with saturated aqueous sodium bicarbonate and brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure to provide 8.6 g of 5-(2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)pentanamide.

Provenance & Evidence