Oxalyl chloride → HCID 86615153, compound

Participants

Reaction Steps

A solution of oxalyl chloride (2.04 mL, 23.4 mmol) in dichloromethane (15 mL) was added dropwise to a suspension of 6-(2-propyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]hexanoic acid (2.56 g, 7.8 mmol) in dichloromethane (38 mL) containing one drop of DMF. The reaction mixture was stirred at ambient temperature for 1.75 hours, and then additional oxalyl chloride (0.35 mL, 4.1 mmol) was added. The reaction was stirred for an additional 45 minutes and then concentrated under reduced pressure to provide 6-(2-propyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]hexanoyl chloride.

Provenance & Evidence