Ammonia → HCID 57447112, compound

Participants

Reaction Steps

Ethyl (4-amino-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)acetate (0.80 g), a solution of ammonia in methanol (35 mL of 7 N), and ammonium chloride (0.50 g) were heated in a sealed pressure vessel at 150° C. for 20 hours. The volatiles were removed under reduced pressure, and the solid residue was triturated with saturated aqueous sodium bicarbonate for one hour, isolated by filtration, and washed with water. The solid was recrystallized from methanol/water, and the crystals were washed sequentially with 25% aqueous sodium hydroxide (2×25 mL) and water (2×25 mL) and dried overnight in a vacuum oven at 70° C. to provide 0.120 g of 2-(4-amino-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)acetamide as light tan crystals, mp>300° C.

Provenance & Evidence