m-Chloroperbenzoic acid → HCID 69506733, compound

Participants

Reaction Steps

The methods described in Part B of Example 60 were used to treat ethyl 2,2-dimethyl-3-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)propanoate (7.2 g, 22 mmol) with mCPBA (9.6 g of 77% pure material), followed by trichloroacetyl isocyanate (3.1 mL, 26 mmol), followed by sodium methoxide (20 mL of 25% in methanol). After the collection of the precipitate, the filtrate was concentrated under reduced pressure, and the residue was mixed with methanol (50 mL). The resulting solid was isolated by filtration, and the isolated solids were combined to provide 2.3 g of methyl 3-(4-amino-2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)-2,2-dimethylpropanoate.

Provenance & Evidence