HCID 69506750, compound → HCID 69506811, compound

Participants

Reaction Steps

A suspension of 5% platinum on carbon (1.2 g) and ethyl 1-{[(3-nitroquinolin-4-yl)amino]methyl}cyclohexanecarboxylate (11.7 g, 32.7 mmol) in acetonitrile (100 mL) was placed under hydrogen pressure (3 atm, 2.1×105 Pa) on a Parr apparatus for five hours and filtered through a layer of CELITE filter agent. The filtrate was concentrated under reduced pressure to provide 9.60 g of ethyl 1-{[(3-aminoquinolin-4-yl)amino]methyl}cyclohexanecarboxylate as an orange oil that solidified upon standing.

Provenance & Evidence