Ethoxyacetyl chloride → HCID 69506831, compound

Participants

Reaction Steps

A solution of ethoxyacetyl chloride (3.95 g, 32.3 mmol) in acetonitrile (10 mL) was added to a solution of ethyl 1-{[(3-aminoquinolin-4-yl)amino]methyl}cyclohexanecarboxylate (9.60 g, 29.3 mmol) in acetonitrile (200 mL), and the resulting mixture was stirred for five hours at ambient temperature. A precipitate was present and was isolated by filtration, washed with cold acetonitrile, and dried overnight under vacuum to provide 10.18 g of ethyl 1-[({3-[(ethoxyacetyl)amino]quinolin-4-yl}amino)methyl]cyclohexanecarboxylate hydrochloride.

Provenance & Evidence