Pyridine → HCID 86657961, compound

Participants

Reaction Steps

N-{5-[(3-Amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide (120 mg, 0.34 mmol) produced in Example 1(x) was dissolved in N,N-dimethylformamide (1.5 mL), 1-isocyanato-4-(trifluoromethoxy)benzene (70 μl, 0.46 mmol) was added, and the mixture was stirred at room temperature for 12 hr. 1-Isocyanato-4-(trifluoromethoxy)benzene (70 μL, 0.46 mmol) was further added to the reaction mixture, and the mixture was further stirred at 70° C. for 3 hr. Pyridine (1.5 mL) was added to the reaction mixture, and the mixture was further stirred at 70° C. for 2 hr. The reaction mixture was diluted with ethyl acetate (20 mL), and washed successively with saturated aqueous sodium hydrogen carbonate solution (20 mL) and saturated brine (10 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained residue was purified by basic silica gel column chromatography (ethyl acetate/hexane=50/50→100/0), and the obtained solution was concentrated under reduced pressure. The residue was recrystallized from ethyl acetate to give the title compound (69 mg, 37%) as a colorless powder.

Provenance & Evidence