Trifluoroacetic acid → HCID 86657962, compound

Participants

Reaction Steps

To trifluoroacetic acid (144 mL) was added tert-butyl methyl{3-[(trifluoroacetyl)amino]phenyl}carbamate (47.8 g, 0.150 mol) at 0° C., and the mixture was stirred for 1 hr. The reaction mixture was concentrated under reduced pressure, ethyl acetate (500 ml) was added to the residue, and the mixture was washed successively with aqueous sodium hydrogen carbonate solution (200 ml) and saturated brine (200 mL). The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure, and the precipitate was collected by filtration to give the title compound (29.2 g, 89%) as a pale-green powder.

Provenance & Evidence