p-(Trifluoromethoxy)phenyl isocyanate → HCID 58451290, compound

Participants

Reaction Conditions

Reaction Steps

N-[5-(3-Amino-4-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide (150 mg, 0.44 mmol) was dissolved in pyridine (3.0 mL), 1-isocyanato-4-(trifluoromethoxy)benzene (99 μL, 0.66 mmol) was added, and the mixture was stirred at 70° C. for 2 hr. 1-Isocyanato-4-(trifluoromethoxy)benzene (20 μL, 0.13 mmol) was added to the reaction mixture, and the mixture was further stirred at 70° C. for 3 hr. The obtained suspension was cooled to room temperature, and diluted with ethyl acetate (5 mL), tetrahydrofuran (1 mL) and n-hexane (5 mL). The precipitated resultant product was collected by filtration to give the title compound (177 mg, 74%) as a colorless powder.

Provenance & Evidence