Ethyl Acetate → HCID 86657979, compound

Participants

Reaction Steps

A solution of N-[5-(5-amino-2-methylphenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide (41 mg, 0.12 mmol) produced in Reference Example 1,3-(3-pyridyl)acrylic acid (22 mg, 0.15 mmol), HOBt (20 mg, 0.15 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (28 mg, 0.15 mmmo) in N,N-dimethylformamide (3 mL) was stirred at room temperature overnight. Ethyl acetate (3 mL) and water (3 mL) were added to the reaction mixture, and the organic layer was dehydrated with Presep Tube manufactured by Wako Pure Chemical Industries, Ltd, and concentrated. Dimethyl sulfoxide was added to the residue, and methanol was further added. The precipitate was collected by filtration, washed with methanol and dried to give the title compound (28.6 mg, 51%) as a powder.

Provenance & Evidence