Chlorobenzene → 2,4,6-Trifluorobenzoyl chloride

HRID 2366813Notes

Reaction equation

HRID 2366813 reaction equation
[F:1][C:2]1[CH:25]=[C:24]([F:26])[CH:23]=[C:22]([F:27])[C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([CH:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)=[O:14])[N:8]=1)=[O:5].NC1N=C(C(C2CCN(C)CC2)=O)C=CC=1.[Cl:44]C1C=CC=CC=1>>[F:1][C:2]1[CH:25]=[C:24]([F:26])[CH:23]=[C:22]([F:27])[C:3]=1[C:4]([Cl:44])=[O:5].[ClH:44].[F:1][C:2]1[CH:25]=[C:24]([F:26])[CH:23]=[C:22]([F:27])[C:3]=1[C:4]([NH:6][CH:7]1[CH2:12][CH2:11][CH2:10][CH:9]([C:13]([CH:15]2[CH2:16][CH2:17][N:18]([CH3:21])[CH2:19][CH2:20]2)=[O:14])[NH:8]1)=[O:5]

Participants

5

Reactant 3

HCID 7964ChlorobenzeneHCID 11401723(6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanoneHCID 11610526Lasmiditan

Product 2

HCID 1448952,4,6-Trifluorobenzoyl chlorideHCID 67451910HCID 67451910, compound

Procedure

The present invention relates to a process for preparing 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide or a salt thereof comprising the step of: reacting (6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone or a salt thereof with 2,4,6-trifluorobenzoylchloride in the presence of chlorobenzene to yield 2,4,6-trifluoro-N-[6-(1-methyl-piperidin-4-ylcarbonyl)-piperidin-2-yl]benzamide hydrochloride.

Sources & evidence

ORD record
ord-20967b6cfb754b4db06c6c8d7b533957
Source dataset
uspto-grants-2014_04
Patent number
US08697876B2

Reaction notes

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