2,4,6-Trifluorobenzoyl chloride → HCID 67451829, compound

Participants

Reaction Steps

The present invention is directed to a process for preparing 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide or a pharmaceutically acceptable salt thereof e.g., the hemi-succinate salt comprising the step of: reacting (6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone (V) with 2,4,6-trifluorobenzoylchloride in the presence of chlorobenzene to yield 2,4,6-trifluoro-N-[6-(1-methyl-piperidin-4-ylcarbonyl)-piperidin-2-yl]benzamide (VI) hydrochloride.

Provenance & Evidence