Acetyl chloride → HCID 86669242, compound

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Reaction Steps

The remaining 1,1-dimethylethyl 4-{5-[(cis)-1-acetyl-2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]-2-pyridinyl}-1-piperazinecarboxylate was dissolved in methanol and 0.5 mL acetyl chloride was added. Solvents were evaporated to yield Example 9, 1-methylethyl {(cis)-1-acetyl-2-methyl-6-[6-(1-piperazinyl)-3-pyridinyl]-1,2,3,4-tetrahydro-4-quinolinyl}carbamate hydrochloride as a pale yellow solid (40 mg). LCMS (Method C): Rt=0.59, MH+=452

Provenance & Evidence