Hydrochloric Acid → HCID 86669245, compound

Participants

Reaction Conditions

Reaction Steps

1,1-Dimethylethyl 4-({4-[(cis)-1-acetyl-2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]phenyl}methyl)hexahydro-1H-1,4-diazepine-1-carboxylate (for a preparation see Intermediate 11) (78 mg, 0.135 mmol) was dissolved in methanol (3 mL) and to this was added 1.25M HCl in methanol (1 mL, 1.250 mmol). The reaction vessel was sealed and heated in Emrys Optimiser microwave to 70° C. for 2 hr. After cooling the reaction was reduced in vacuo to give a colourless solid and placed under high vacuum for 1 hr. Transferred to vial using methanol, reduced, and then redissolved in ether to give a colourless solid (66 mg). LCMS (Method A): Rt=0.96, MH+=479

Provenance & Evidence