Hydrochloric Acid → HCID 86669250, compound

Participants

Reaction Conditions

Reaction Steps

1,1-Dimethylethyl-4-({-4-[(cis)-1-acetyl-2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]phenyl}methyl)-1-piperazinecarboxylate (for a preparation see Intermediate 8) (98 mg, 0.174 mmol) was dissolved in methanol (2 mL) and to this was added 1.25M HCl in methanol. (0.305 mL, 0.382 mmol) and stirred overnight. 1.25M HCl in methanol. (0.305 mL, 0.382 mmol) was added and the reaction was heated in a sealed vessel to 70° C. in an optimiser microwave for 15 min followed by a further 30 min. 2 eqv of 1.25M HCl in methanol was added and the reaction mixture heated in the microwave under the same conditions for a further 1 hr. The reaction mixture was reduced in vacuo to give a white solid (86 mg). LCMS (Method A): Rt=0.92, MH+=465

Provenance & Evidence