Hydrochloric Acid → HCID 86669273, compound

Participants

Reaction Steps

A solution of 1-methylethyl((2S,4R)-1-acetyl-6-{5-[2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)ethyl]-1,2,4-oxadiazol-3-yl}-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl)carbamate (for a preparation, see Intermediate 76) (260 mg, 0.518 mmol) in 1,4-Dioxane (1 mL) was treated with HCl (4N in 1,4-dioxane, 1.00 mL, 4 mmol) and the resulting mixture was stirred at room temperature for 16 h. Et2O (10 mL) was then added and the precipitate formed was triturated then filtered off to give 1-methylethyl {(2S,4R)-1-acetyl-6-[5-(2-aminoethyl)-1,2,4-oxadiazol-3-yl]-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl}carbamate hydrochloride (195 mg, 0.446 mmol, 86%) as an off white solid.

Provenance & Evidence