Trifluoroacetic acid → HCID 67203682, compound

Participants

Reaction Steps

Trifluoracetic acid (1 mL) was added at room temperature to a solution of 1,1-dimethylethyl {(cis)-4-[1-acetyl-2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]-1H-imidazol-1-yl}acetate (for a preparation see Example 91) (1.26 g, 2.68 mmol) in DCM (5 mL). The reaction mixture was allowed to stand at room temperature for 16 h then concentrated in vacuo. The residue was co-evaporated twice with toluene then triturated with Et2O to give {4-[(cis)-1-acetyl-2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]-1H-imidazol-1-yl}acetic acid trifluoroacetate (1.19 g, 2.252 mmol, 84%) as an off-white solid.

Provenance & Evidence