Acetic Anhydride → HCID 52934563, compound

Participants

Reaction Steps

A solution of 1,1-dimethylethyl 3-{-4-[2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]-1H-imidazol-1-yl}propanoate (for a preparation see Intermediate 93) (1.46 g, 3.3 mmol) in acetic anhydride (3 mL) was allowed to stand at room temperature for 16 h then most of the solvent was removed in vacuo. The residue was co-evaporated twice with toluene. Its purification by flash chromatography on silica gel (gradient: 0 to 2% MeOH in DCM) gave 1,1-dimethylethyl 3-{(cis)-4-[1-acetyl-2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]-1H-imidazol-1-yl}propanoate (1.055 g, 2.177 mmol, 66%) as a colourless solid.

Provenance & Evidence