Acetic Anhydride → HCID 86669276, compound

Participants

Reaction Steps

A solution of 1,1-dimethylethyl {(cis)-4-[2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]-1H-imidazol-1-yl}acetate (for a preparation see Intermediate 88) (1.0 g, 2.33 mmol) in acetic anhydride (2 mL) was allowed to stand at room temperature for 16 h then most of the solvent was concentrated in vacuo. The residue was co-evaporated twice with toluene. Purification of the resulting residue by flash chromatography on silica gel (gradient: 0 to 2% MeOH in DCM) gave 1,1-dimethylethyl {(cis)-4-[1-acetyl-2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]-1H-imidazol-1-yl}acetate (862 mg, 1.832 mmol, 78%) as a pale yellow solid.

Provenance & Evidence