Thionyl Chloride → HCID 21315732, compound

Participants

Reaction Steps

6-carboxy-2'-isopropoxy-5'-methyl-flavone (4.8 g) in dioxane (30 ml) was treated with thionyl chloride (4 ml) at the reflux temperature for 2 hours. After cooling, the reaction mixture was evaporated to dryness and reacted with an excess of anhydrous ethanol at 50° C. for 1 hour. The mixture was concentrated to a small volume and diluted with water so obtaining, by filtration, 6-carbethoxy-2'-isopropoxy-5'-methyl-flavone (4.7 g).

Provenance & Evidence