HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 57803317, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | (3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514396 | — |
| Reactant | HCID 57803386 | HCID 57803386 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57803317 | HCID 57803317 | — |
Reaction Steps
To a solution of 1-[4-(trifluoromethyl)pyridin-2-yl]-1H-imidazole-4-carboxylic acid (120 mg, 0.47 mmol) and tert-butyl (3S)-pyrrolidin-3-ylcarbamate (87 mg, 0.47 mmol) in DMF (3 mL) was added benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (210 mg, 0.47 mmol) followed by triethylamine (0.20 mL, 1.4 mmol). The reaction was stirred at room temperature overnight and purified by HPLC to give the title compound. MS (M+H) 426.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697870B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-c1dd716b9c69403f88b4c78be4987985 |
| Source note | uspto-grants-2014_04 |