Trifluoroacetic acid → HCID 46866394, compound

Participants

Reaction Steps

A mixture of (R)-tert-butyl 3-((S)-1-(4-(3,3-dimethyl-2-oxoindolin-1-yl)piperidin-1-yl)-1-oxo-4-phenylbutan-2-ylcarbamoyl)piperidine-1-carboxylate (615 mg, 0.997 mmol, EXAMPLE 1, Alternative Method, Step 1) and trifluoroacetic acid (2 mL) was stirred for 20 min and concentrated. The residue was diluted with dichloromethane and basified by saturated sodium hydrogen carbonate aqueous solution. The organic layer was dried over sodium sulfate and concentrated in vacuo. The crude product was purified by amine gel column chromatography (dichloromethane/methanol, gradient) to give the title compound (430 mg, 83%) as an amorphous solid.

Provenance & Evidence