Triethylamine → HCID 66616147, compound

Participants

Reaction Steps

To a solution of 2-(2-bromo-5-fluorophenyl)-2-methylpropanoic acid (510 mg, 1.95 mmol, EXAMPLE 44, Step 1) in tetrahydrofuran (20 mL) were added triphosgene (197 mg, 0.66 mmol) and triethylamine (0.288 mL, 2.05 mmol). The mixture was stirred at room temperature for 30 min and was filtered. The filtrate was added drop-wise into a solution of 1-benzyl-4-aminopiperidine (372 mg, 1.95 mmol) and triethylamine (0.288 mL, 2.05 mmol) in tetrahydrofuran (20 mL). The mixture was stirred at room temperature for overnight.

Provenance & Evidence