HCID 66616105, compound → HCID 46912482, compound

Participants

Reaction Steps

A mixture of tert-butyl (S)-1-((S)-1-(4-(3,3-dimethyl-2-oxoindolin-1-yl)piperidin-1-yl)-1-oxo-4-phenylbutan-2-ylcarbamoyl)pyrrolidin-3-yl(methyl)carbamate (267 mg, 0.42 mmol, EXAMPLE 47: Alternative Method, Step 1) in dichloromethane-trifluoroacetic acid (1:1, 6 mL) was stirred at room temperature for 1 h. The mixture was concentrated, diluted with dichloromethane, and washed with saturated sodium hydrogen carbonate aqueous solution. The organic layer was dried over sodium sulfate, filtered and concentrated under reduced pressure. The residual oil was purified by preparative HPLC (32-96% methanol in 0.01% ammonia aqueous solution) and by amino gel column chromatography to give the title compound (209 mg, 93%) as a colorless oil.

Provenance & Evidence