Cyclohexane → HCID 49805573, compound

Participants

Reaction Steps

The process is performed according to the procedure described in Example 1, step 1.3. Starting with 0.053 g (0.19 mmol) of (3aR,4R,6aS)-4-[(4′-ethoxybiphenyl-3-yl)oxy]octahydrocyclopenta[c]pyrrole, obtained in step 14.3., 0.04 mL (0.23 mmol) of N,N-diisopropylethylamine and 0.068 g (0.21 mmol) of thiazol-4-ylmethyl 4-nitrophenyl carbonate (WO 2008/013 834), and after chromatography on silica gel, eluting with a 95/5 and then a 90/10 mixture of cyclohexane and ethyl acetate, 0.055 g (63%) of expected product is obtained in the form of an oil.

Provenance & Evidence